Academic
Publications
Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults

Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults,10.1249/MSS.0b013e3181a2f646,Medicine and Science in Sports and Exerci

Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults   (Citations: 7)
BibTex | RIS | RefWorks Download
MARLEEN H. M. DE MOOR, YONG-JUN LIU, DORRET I. BOOMSMA, JIAN LI, JAMES J. HAMILTON, JOUKE-JAN HOTTENGA, SHAWN LEVY, XIAO-GANG LIU, YU-FANG PEI, DANIELLE POSTHUMA, ROBERT R. RECKER, PATRICK F. SULLIVANhttp://academic.research.microsoft.com/io.ashx?type=5&id=6858995&selfId1=0&selfId2=0&maxNumber=12&query=
DE MOOR, M. H., Y. LIU, D. I. BOOMSMA, J. LI, J. J. HAMILTON, J. HOTTENGA, S. LEVY, X. LIU, Y. PEI, D. POSTHUMA, R. R. RECKER, P. F. SULLIVAN, L. WANG, G. WILLEMSEN, H. YAN, E. J. DE GEUS, and H. DENG. Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults. Med. Sci. Sports Exerc., Vol. 41, No. 10, pp. 2009. Introduction: The objective of this study was to identify genetic variants that are associated with adult leisure time exercise behavior using genome-wide association (GWA) in two independent samples. Methods: Exercise behavior was measured in 1644 unrelated Dutch and 978 unrelated American adults of European ancestry with detailed questions about type, frequency, and duration of exercise. Individuals were classified into regular exercisers or nonexercisers using a threshold of 4 METIh (metabolic equivalentsIhours per week). GWA analyses of È1.6 million observed and imputed Single Nucleotide Polymorphism (SNP) were conducted in both samples independently using logistic regression in SNPTEST, including sex, age, and body mass index as covariates. A meta-analysis of the results was performed using the weighted inverse variance method in METAL. Results: Thirty-seven novel SNPs in the PAPSS2 gene and in two intergenic regions on chromosomes 2q33.1 and 18p11.32 were associated with exercise participation (pooled P values G1.0 10j5). Previously reported associations (ACE, CASR, CYP19A1, DRD2, LEPR ,a ndMC4R genes) or linkage findings (2p22.3, 4q28, 4q31.21 7p13, 9q31, 11p15, 13q22, 15q13, 18q12.2, 18q21.1, 19p13.3, and 20q12) were not replicated, although suggestive evidence was found for association to rs12405556 in the LEPR gene (pooled P value 9.7 10j4 ;A merican sample,P value 9.8 10j5 )a nd for association to rs8036270 in the GABRG3 gene (pooled P value 4.6 10j5) in the linkage region 15q12-13. Conclusions: The heritability of leisure time exercise behavior is likely to be accounted for by many genetic variants with small effect size. These can be detected by GWA as was shown here for the PAPSS2 gene, but larger samples with genome-wide genotypes and high-quality exercise data are needed for further progress.
Journal: Medicine and Science in Sports and Exercise - MED SCI SPORT EXERCISE , vol. 41, no. 10, pp. 1887-1895, 2009
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...However, knowledge on the genes and DNA sequence variants that contribute to the genetic variance in physical activity or physical fitness is scarce [26, 27]...

    Urho M. Kujala. Physical activity, genes, and lifetime predisposition to chronic disea...

    • ...This approach, known as GWAS, has been successfully applied to the search for genes in complex diseases or traits like type 2 diabetes [39], body composition [40], Crohn’s disease [41] and a first GWAS has been published on physical activity behavior [42]...

    Stephen M. Rothet al. Fundamental Concepts in Exercise Genomics

    • ...Given that there is little known regarding the physiologic pathways through which physical activity is regulated, the strict use of a candidate gene approach without integrating results from positional cloning approaches can lead to false positives as has been recently shown by De Moor et al. [49] Thus, determination of candidate genes for the regulation of physical activity requires the integration of both positional cloning and candidate ...
    • ...DeMoor et al. [49] Human Exercise participation (survey) 2 200.984 Mbp 200.865–200.984 Mbp DeMoor et al. [49] Human Exercise participation (survey) 10 89.433 Mbp 89.400–89.435 Mbp DeMoor et al. [49] Human Exercise participation (survey) 18 1.585 Mbp 1.585–1.591 Mbp Cai et al. [69] Human siblings % Time in sedentary activities (accelerometry) 18 63–71 cM Not reported...
    • ...DeMoor et al. [49] Human Exercise participation (survey) 2 200.984 Mbp 200.865–200.984 Mbp DeMoor et al. [49] Human Exercise participation (survey) 10 89.433 Mbp 89.400–89.435 Mbp DeMoor et al. [49] Human Exercise participation (survey) 18 1.585 Mbp 1.585–1.591 Mbp Cai et al. [69] Human siblings % Time in sedentary activities (accelerometry) 18 63–71 cM Not reported...
    • ...DeMoor et al. [49] Human Exercise participation (survey) 2 200.984 Mbp 200.865–200.984 Mbp DeMoor et al. [49] Human Exercise participation (survey) 10 89.433 Mbp 89.400–89.435 Mbp DeMoor et al. [49] Human Exercise participation (survey) 18 1.585 Mbp 1.585–1.591 Mbp Cai et al. [69] Human siblings % Time in sedentary activities (accelerometry) 18 63–71 cM Not reported...
    • ...A more recent study from De Moor et al. [49] took great strides toward reducing the possible exclusion of smaller variance QTL by conducting a GWAS on 1,644 unrelated Dutch and 978 unrelated American adults...
    • ...Potential candidate genes (those with at least two lines of evidence) Glucose transporter 4 (SLC2A4) FR, QTL, within mini-muscle QTL, HD [38, 49, 60, 61, 64, 65, 83]...
    • ...For example, De Moor et al. [49] identified several genomic markers significantly associated with exercise participation located within the intron region of the 3¢-phosphoadenosine 5¢-phosphosulfate synthase 2 (PAPSS2) gene...
    • ...To this end, it is interesting that two of the three identified QTL associated with physical activity in humans [49] localize within intergenic areas of the genome...

    J. Timothy Lightfoot. Can You Be Born a Couch Potato? The Genomic Regulation of Physical Act...

Sort by: