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Leptin Reduces Ovariectomy-Induced Bone Loss in Rats

Leptin Reduces Ovariectomy-Induced Bone Loss in Rats,BARTOLOME BURGUERA,LORENZ C. HOFBAUER,THIERRY THOMAS,FRANCESCA GORI,GLENDA L. EVANS,SUNDEEP KHOSL

Leptin Reduces Ovariectomy-Induced Bone Loss in Rats   (Citations: 41)
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Bone mineral density increases with fat body mass, and obe- sity has a protective effect against osteoporosis. However, the relationship between fat body mass and bone mineral density is only partially explained by a combination of hormonal and mechanical factors. Serum leptin levels are strongly and di- rectly related to fat body mass. We report here the effects of leptin administration compared with estrogen therapy on ovariectomy-induced bone loss in rats. Leptin was effective at reducing trabecular bone loss, trabecular architectural changes, and periosteal bone formation. Interestingly, the combination of estrogen and leptin further decreased bone turnover compared with that in estrogen-treated ovariecto- mized rats. Leptin also significantly increased osteoprote- gerin mRNA steady state levels and protein secretion and decreased RANK ligand mRNA levels in human marrow stro- mal cells in vitro. Our findings suggest that leptin could mod- ulate bone remodeling in favor of a better bone balance in rats. This study is the first evidence that leptin therapy has a sig- nificant effect in preventing ovariectomy-induced bone loss, and this effect may at least in part be mediated by the osteo- protegerin/RANK ligand pathway. (Endocrinology 142: 3546 -3553, 2001)
Published in 2010.
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    • ...and to reduce bone loss in ovariectomized rats ...

    Der-Chih Yanget al. cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG m...

    • ...Some studies reported that serum leptin acts as a potent inhibitor of bone formation in vivo and that increasing serum leptin levels leads to a reduction in bone mass (5, 6). Contrary to this, leptin promoted bone formation in vitro (9, 28) and also had a protective effect on ovariectomy-induced bone loss in rats (2)...

    Ivana Barbaricet al. An ENU-induced mutation in the Ankrd11 gene results in an osteopenia-l...

    • ...It was also suggested that leptin could modulate bone remodeling in favor of better balance [Burguera et al., 2001; Martin et al., 2005]...
    • ...treatment. Indeed, the expression of OPG by bone marrow stromal cells/osteoblasts in vitro was reported to be increased by leptin [Burguera et al., 2001; Gordeladze et al., 2002]...
    • ...Burguera et al. described that 24 h of leptin treatment (2.4 mg/ml) stimulates OPGmRNAlevelbyconditionallyimmortalized human marrow stromal cells [Burguera et al., 2001]...

    M. Lamghariet al. Leptin effect on RANKL and OPG expression in MC3T3-E1 osteoblasts

    • ... However, the effects of leptin on bone mass in rodents remains controversial because leptin protects against ovariectomy-induced bone loss in rats (...

    Josef V. Silhaet al. Plasma Adipokines and Body Composition in Response to Modest Dietary M...

    • ...In femal e leptin inhibited bone resorption (Burguera et al., 2001), hemodialysis patients, a near significant and inverse also it have been shown that leptin deficient mice have correlation between serum leptin and serum increased bone mass associated with increased rate of phosphorus (r = -0.54, p = 0.057) was existed, in thi s bone formation (Ducy et al., 2000)...
    • ...experimental data showing decrease osteoblastic significant inverse correlation between dialysis efficacy activity related to the administration of leptin in viv o and serum leptin a significant positive correlation (Coen et al., 2003, Burguera et al., 2001) or the addiction between hemodialysis dosage and serum leptin were of leptin to preosteoclastic in viro (Coen et al., 2003, seen too, moreover in this group a very near significant ...
    • ...experimental data showing decrease osteoblastic significant inverse correlation between dialysis efficacy activity related to the administration of leptin in viv o and serum leptin a significant positive correlation (Coen et al., 2003, Burguera et al., 2001) or the addiction between hemodialysis dosage and serum leptin were of leptin to preosteoclastic in viro (Coen et al., 2003, seen too, moreover in this group a very near significant ...

    Unknown. Association of Serum Leptin with Various Biochemical Parameters of Bon...

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