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Enhanced ability of dendritic cells to stimulate innate and adaptive immunity on short-term incubation with zoledronic acid

Enhanced ability of dendritic cells to stimulate innate and adaptive immunity on short-term incubation with zoledronic acid,Francesca Fiore,Barbara Ca

Enhanced ability of dendritic cells to stimulate innate and adaptive immunity on short-term incubation with zoledronic acid   (Citations: 23)
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V9/V 2( ) T cells play a major role in innate immunity against microbes, stressed, and tumor cells. They represent less than 5% of peripheral blood lympho- cytes but can be activated and expanded in vitro by aminobisphosphonates (ABP)- treated monocytes. The aim of this work was to determine whether ABP-treated den- dritic cells (DCs) can also activate T cells and regulate immune responses mediated by conventional T cells. Highly purified immature (iDC) and mature DC (mDC) were generated from peripheral blood mono- cytes of healthy donors and incubated with zoledronic acid (Zol) for 24 hours. Zol- treated iDC and mDC retained their immu- nostimulatory properties and induced the vigorous expansion of central memory and effector memory T cells. T cells dis- played antitumor activity and appropriate cell surface antigens to target secondary lymphoid organs and exert costimulatory activity. Antigen-specific MHC-restricted immune responses, mediated by conven- tional T cells, were improved by the con- current T-cell activation. In conclusion, large numbers of T cells with effector and costimulatory activities are rapidly gen- erated by Zol-treated iDC/mDC. This strategy is worthy of further investigation to improve adoptive cell therapy and vaccine interventions against tumors and infec- tions. (Blood. 2007;110:921-927)
Published in 2007.
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