Myeloperoxidase and Cardiovascular Disease

Myeloperoxidase and Cardiovascular Disease,Stephen J. Nicholls,Stanley L. Hazen

Myeloperoxidase and Cardiovascular Disease   (Citations: 63)
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Myeloperoxidase (MPO) is a leukocyte-derived enzyme that catalyzes the formation of a number of reactive oxidant species. In addition to being an integral component of the innate immune response, evidence has emerged that MPO-derived oxidants contribute to tissue damage during inflammation. MPO-catalyzed reactions have been attributed to potentially proatherogenic biological activities throughout the evolution of cardiovascular disease, including during initiation, propagation, and acute complication phases of the atherosclerotic process. As a result, MPO and its downstream inflammatory pathways represent attractive targets for both prognostication and therapeutic intervention in the prophylaxis of atherosclerotic cardiovascular disease. (Arterioscler Thromb Vasc Biol. 2005;25:1102-1111.)
Published in 2010.
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