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Feedlot Performance of Steers and Bulls Actively Immunized Against Gonadotropin-Releasing Hormone

Feedlot Performance of Steers and Bulls Actively Immunized Against Gonadotropin-Releasing Hormone,T. E. Adams,B. M. Adams

Feedlot Performance of Steers and Bulls Actively Immunized Against Gonadotropin-Releasing Hormone   (Citations: 24)
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Feedlot performance and testicular and pituitary function were assessed in cattle actively immunized against GnRH. In Trial 1, 50 steers were either unimmunized (n = 101, actively immunized against keyhole limpet hemocyanin (KLH; n = 101, or immunized against a GnRH-KLH conjugate (n = 30). Fifteen of 30 steers immunized against GnRH-KLH received a secondary immuni- zation 8 wk after primary immunization. Antibod- ies against GnRH were not evident in unim- munized steers or steers actively immunized a.gainst KLH. Antibodies against GnRH were noted in all immunized animals (n = 30) within 6 wk of primary immunization and anti-GnRH anti- body concentrations became maximal 20 to 24 wk after immunization. The increasing anti-GnRH titer in immunized steers was associated with decreasing serum concentrations of LH. Serum concentrations of LH were depressed (P e .05) within 8 wk of primary immunization and reached a nadir by wk 20. The patterns of increase in GnRH titer and decrease in serum concentrations of LH did not differ (P > .05) in animals receiving primary immunization alone or primary and sec-
Published in 2010.
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