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Phenotypic and functional properties of murine yS T cell clones derived from malaria immunized, a(3 T cell-deficient mice

Phenotypic and functional properties of murine yS T cell clones derived from malaria immunized, a(3 T cell-deficient mice,Moriya Tsuji,Cassandra L. Ey

Phenotypic and functional properties of murine yS T cell clones derived from malaria immunized, a(3 T cell-deficient mice   (Citations: 9)
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Six murine T cell clones expressing 76 TCR were generated from malaria Immunized, ap" T cell- deficient mice. Phenotypic characterization of these clones has revealed that, In contrast to conventional ap" T cells, there Is a considerable degree of heterogeneity among these 76 clones with regard to their surface markers and their lymphokine profile. One clone was found to display significant anti-parasite activity In vivo upon adoptive transfer. We attempted to determine whether the protective clone differs in one or more key characteristics from the non-protective clones. Although no obvious pattern peculiar to the protective 78 clone was observed, It appears that more than one parameter may, In combination, define a distinct protective phenotype, and thus explain the functional difference between the protective and non-protective 76 clones.
Published in 2010.
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    • ... yoelii sporozoite-immunized mice are MHC unrestricted, cross-react with various bacterial antigens, variably produce pro-inflammatory or anti-inflammatory cytokines after non-specific activation in vitro and vary in their anti-parasitic activit...

    Eleanor M. Rileyet al. Innate immunity to malaria

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