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The Pfam Protein Families Database

The Pfam Protein Families Database,10.1093/nar/30.1.276,Nucleic Acids Research,Alex Bateman,Ewan Birney,Lorenzo Cerutti,Richard Durbin,Laurence Ettwil

The Pfam Protein Families Database   (Citations: 1464)
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ABSTRACT Pfam is a ,large collection of protein multiple sequence alignments and profile hidden Markov models. Pfam is available on the World Wide Web in the UK at http://www.sanger.ac.uk/Software/Pfam/, in Sweden at http://www.cgb.ki.se/Pfam/, in France at http://pfam.jouy.inra.fr/ and in the ,US at http:// pfam.wustl.edu/. The latest version (6.6) of Pfam contains 3071 families, which match 69% of proteins inSWISS-PROT 39 and TrEMBL 14. Structural data, where available, have been utilised to ensure that Pfam families correspond with structural domains, and to improve domain-based annotation. Predictions ofnon-domain regions are now also included. In addition to secondary structure, Pfam multiple sequence alignments now contain active site residue mark-up. New search tools, including taxonomy search and domain query, greatly add to the functionality and usability of the Pfam resource.
Journal: Nucleic Acids Research - NAR , vol. 30, no. 1, pp. 276-280, 2002
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