Top publications in molecular biology 201–300 of 367,162 results
Publications Citations  
201
Adherence of bacteria to hydrocarbons: A simple method for measuring cell-surface hydrophobicity (1980) 570
202
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC) (1997) 570
203
Protein misfolding, evolution and disease (1999) 570
204
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids (2007) 569
205
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL (1998) 568
206
Multiple sequence alignment with the Clustal series of programs (2003) 568
207
DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions (2002) 566
208
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase (1992) 565
209
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate (2001) 564
210
Dali: a network tool for protein structure comparison (1995) 563
211
The InterPro database, an integrated documentation resource for protein families, domains and functional sites (2001) 561
212
Hypervariability of simple sequences as a general source for polymorphic DNA markers (1989) 558
213
The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms (1994) 556
214
The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells (2000) 552
215
SIFT: predicting amino acid changes that affect protein function (2003) 551
216
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells (2000) 550
217
CDD: a Conserved Domain Database for protein classification (2005) 550
218
A modified ninhydrin colorimetric analysis for amino acids (1957) 549
219
MyD88 Is an Adaptor Protein in the hToll/IL1 Receptor Family Signaling Pathways (1998) 546
220
A new version of the RDP (Ribosomal Database Project) (1999) 544
221
Coiled coils: new structures and new functions (1996) 542
222
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing (2007) 540
223
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans (2001) 539
224
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit (1993) 537
225
A system for shotgun DNA sequencing (1981) 536
226
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling (2002) 534
227
SCOP database in 2004: refinements integrate structure and sequence family data (2004) 532
228
Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats (1988) 531
229
PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development (1999) 530
230
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators (1998) 530
231
Positionally Cloned Gene for a Novel Glomerular Protein—Nephrin—Is Mutated in Congenital Nephrotic Syndrome (1998) 529
232
CD-Search: protein domain annotations on the fly (2004) 528
233
PUMA, a Novel Proapoptotic Gene, Is Induced by p53 (2001) 528
234
PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing (1997) 526
235
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate (1993) 524
236
NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins (2007) 523
237
Carotenoids and photoprotection in plants: A role for the xanthophyll zeaxanthin (1990) 522
238
p53 Has a Direct Apoptogenic Role at the Mitochondria (2003) 522
239
Rapid and efficient cosmid cloning (1981) 521
240
Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development (1998) 521
241
MicroRNA maturation: stepwise processing and subcellular localization (2002) 521
242
MIPS: a database for genomes and protein sequences (2002) 519
243
The Ribosomal Database Project (RDP) (1996) 518
244
Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products (1991) 518
245
Loop-mediated isothermal amplification of DNA (2000) 518
246
Signaling to NF B (2004) 518
247
The Ensembl genome database project (2002) 515
248
New functional activities for the p21 family of CDK inhibitors (1997) 515
249
Entrez Gene: gene-centered information at NCBI (2005) 514
250
The p53-mdm-2 autoregulatory feedback loop (1993) 513
251
SMART: a web-based tool for the study of genetically mobile domains (2000) 508
252
Isolation of multipotent adult stem cells from the dermis of mammalian skin (2001) 508
253
The Ribosomal Database Project (RDP-II): sequences and tools for high-throughput rRNA analysis (2005) 507
254
The KEGG databases at GenomeNet (2002) 506
255
TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL (1997) 504
256
Mechanisms of Caspase Activation and Inhibition during Apoptosis (2002) 501
257
Molecular imaging in living subjects: seeing fundamental biological processes in a new light (2003) 500
258
RefSeq and LocusLink: NCBI gene-centered resources (2001) 499
259
Animal mitochondrial genomes (1999) 499
260
AFLP: a new technique for DNA fingerprinting (1995) 498
261
GeneMark.hmm: new solutions for gene finding (1998) 496
262
Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide (1991) 495
263
Multipotent cell lineages in early mouse development depend on SOX2 function (2003) 495
264
Structure, mechanism and regulation of peroxiredoxins (2003) 495
265
Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application (2001) 494
266
NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins (2005) 493
267
Regulation of translation initiation by FRAP/mTOR (2001) 493
268
Met, metastasis, motility and more (2003) 493
269
The BCL2 protein family: opposing activities that mediate cell death (2008) 493
270
jModelTest: Phylogenetic Model Averaging (2008) 492
271
A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae (1993) 490
272
Specificity of microRNA target selection in translational repression (2004) 490
273
S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles (2001) 488
274
Sphingosine1-phosphate: an enigmatic signalling lipid (2003) 488
275
BIND - The Biomolecular Interaction Network Database (2001) 487
276
Proteases to die for (1998) 486
277
Creating new fluorescent probes for cell biology (2002) 485
278
Cellular roles of DNA topoisomerases: a molecular perspective (2002) 485
279
PEST sequences and regulation by proteolysis (1996) 484
280
SMART 5: domains in the context of genomes and networks (2006) 484
281
An improved PCR method for walking in uncloned genomic DNA (1995) 483
282
Ubiquitin promoter-based vectors for high-level expression of selectable and/or screenable marker genes in monocotyledonous plants (1996) 483
283
The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy (1998) 483
284
Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana (1998) 482
285
Computational Identification of Plant MicroRNAs and Their Targets, Including a Stress-Induced miRNA (2004) 482
286
Differential Targeting of Prosurvival Bcl2 Proteins by Their BH3Only Ligands Allows Complementary Apoptotic Function (2005) 482
287
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells (1991) 481
288
The leucine-rich repeat: a versatile binding motif (1994) 479
289
High gradient magnetic cell separation with MACS (1990) 477
290
ESEfinder: a web resource to identify exonic splicing enhancers (2003) 477
291
Reliable genotyping of samples with very low DNA quantities using PCR (1996) 476
292
Bayes Empirical Bayes Inference of Amino Acid Sites Under Positive Selection (2005) 475
293
The complexity of p53 modulation: emerging patterns from divergent signals (1998) 474
294
Smad transcription factors (2005) 474
295
GoMiner: a resource for biological interpretation of genomic and proteomic data (2003) 473
296
PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1) (1992) 472
297
siRNAs can function as miRNAs (2003) 472
298
SMART 4.0: towards genomic data integration (2004) 472
299
Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms (2000) 472
300
Organelle-specific initiation of cell death pathways (2001) 472