RSS for Dendroaspis natriuretic peptide binds to the natriuretic peptide clearance receptorhttp://academic.research.microsoft.com/Rss.aspx?cata=9&id=36262003Search RSS feed for Microsoft Academic SearchMSRA Libra RSS Burner(c)2008 Microsoft Corpration, All right reserved.Mon, 20 May 2013 13:37:26 GMTMon, 20 May 2013 13:37:26 GMTDendroaspis natriuretic peptide binds to the natriuretic peptide clearance receptorhttp://academic.research.microsoft.com/Publication/36262003Mon, 20 May 2013 06:37:26 GMT3626200312Douglas G.. Johns, Zhaohui Ao, Bradley J. Heidrich, Gerald E. Hunsberger, Taylor Graham, Lisa Payne, Nabil Elshourbagy, Quinn Lu, Nambi Aiyar, Stephen A. Douglas: (Citations:12)view publication
Dendroaspis natriuretic peptide (DNP) is a newly-described natriuretic peptide which lowers blood pressure via vasodilation. The natriuretic peptide clearance receptor (NPR-C) removes natriuretic peptides from the circulation, but whether DNP interacts with human NPR-C directly is unknown. The purpose of this study was to test the hypothesis that DNP binds to NPR-C. ANP, BNP, CNP, and the NPR-C ligands AP-811 and cANP(4–23) displaced [125I]-ANP from NPR-C with pM-to-nM Ki values. DNP displaced [125I]-ANP from NPR-C with nM potency, which represents the first direct demonstration of binding of DNP to human NPR-C. DNP showed high pM affinity for the GC-A receptor and no affinity for GC-B (Ki>1000nM). DNP was nearly 10-fold more potent than ANP at stimulating cGMP production in GC-A expressing cells. Blockade of NPR-C might represent a novel therapeutic approach in augmenting the known beneficial actions of DNP in cardiovascular diseases such as hypertension and heart failure.
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