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...far for a near-optimal setting of the mutation rate have intrinsic limitations. a promising guideline is, however...domains as test prob- lems and explore (i) whether optimal mu- tation rates change with time; and (ii) the interactions between the mutation rate and other evolutionary parameters. results sug...
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...applied to subpopulations divided from the original population to enhance the exploring potential and to enrich the diversity
of the crossover templates. thirdly, classical mutation is replaced by a metropolis...as
well as to avoid the problem of choosing the mutation rate. simulation results based on benchmarks demonstrate the effectiveness
of the hybrid heuristic. ...
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...method which adaptively adjusts ea and specifically genetic algorithm (ga) mutation rates. the proposed method incorporates the underlying statistical framework of biological evolutionary models into the...method aims to wisely determine the types of replacing genes in the mutation procedure. to demonstrate the efficacy of the proposed algorithm, the method is evaluated using a...
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...signals associated with increased isolation and the extinction of intermediate populations. the majority of estimates for tajima's d...bottlenecked populations with this data set. estimates of population mutation rate (θ θ θ θ ), population divergence time ( t ), and time to the most recent common ancestor (tmrca...
Published in 2007.
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...for both c4.5, hider and xcs on each problem were tenfold cross-validated, and in the case of hider and
xcs a modest amount of preliminary parameter investigation was done...parameters around well-known
default settings. we find the default settings to be generally robust, but find the mutation rates and ga selection scheme
to be...
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...point process whose
generator captures the probabilistic dynamics over continuous time of birth, mutation, and death, as influenced by each individual’s
trait values, and interactions between individuals. an offspring usually inherits the trait values of her progenitor, except
when a mutation causes the offspring to take an instantaneous mutation step at birth to new...
Published in 2005.
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...of a polymorphic population with mutation and selection
in the specific scales of the biological framework of adaptive dynamics. the population size is assumed to...then we introduce a scaling of the size of mutations and we study the pes in the limit of small mutations. from this
study in the...
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...et_k$. here, we consider the analogous problem for the moran model and prove that as the mutation rate $\mu\to0$, $t_k\sim...in addition, we derive a limiting result on a log scale for the size of $x_k(t)={}$the number of cells with $k$ mutations at time $t$....
Published in 2009.
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...evolving in discrete time under the influence of selection and mutation. beneficial mutations appear at rate u and their selective effects s are...we present an exact solution of the infinite population size limit and provide an estimate of the population size beyond
which it...
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Elliott H. Margulies, Gregory M. Cooper, George Asimenos, Daryl J. Thomas, Colin N. Dewey, Adam Siepel, Ewan Birney, Damian Keefe, Ariel S. Schwartz, Minmei Hou, James Taylor, Sergey Nikolaevhttp://academic.research.microsoft.com/io.ashx?type=5&id=5066201&selfId1=-1&selfId2=-1&maxNumber=12&query=Setting The Mutation Rate: Scope And Limitations Of The 1/L Heuristic
...a key component of the ongoing encode project involves rigorous comparative sequence analyses for the initially targeted 1% of the human genome. here, we present...important discrepancies relating to both the underlying alignments and the specific algorithms. however, by integrating the results across the alignments and constraint-detecting methods, we produced...